Hello everyone. Today i bring you the answers after my very indepth time consuming research... Hold on tight... So I suffer from PE my entire life. Pretty much since i was 15 a lot of porn and dopamine increasing related activities. 1st sex when i was 20. realised thst time that something is wrong but i have just put it down to not enough sex practice. i am 30 now and i still suffer from PE altough i had a lot of sex recently. Yes relaxing BC muscle helps last slightly longer Yes erectile dysfunctions increase PE But... thats not the issue here which i figured out on my case. In my research i found out that PE can be due to 3 things: -erectile dysfunction -tight pelvic floor (mostly tight contracting BC muscle) -hormonal imbalances (serotonin / dopamine systems) Not waiting long i started tests I spoke to my doctor and got done blood tests for erectile dysfunction. Everything was within range but... It is proven in studies that people with PE have: -lower TSH levels -lower prolactin levels -higher FSH levels -lower LH level (independent risk factor for PE) My results were as follows Tsh = 0.95 ( range 0.35 - 5.5) Prolactin 185 (45 - 375) Fsh 5.2 (1 - 18) LH 3.5 (2.0 - 9.0) So there are significant hormones on lo side of spectrum ? Cause of PE. In my research i have targetted ED first. I have started 5mg tadalafil daily for ED for 2 weeks. It improved my erections in terms of size and also how long they last so I have some mild ED. Didnt change much in termsnof PE. I was lasting slightly longer but difference in my opinion was non existan as from 30sec lasting around minute is not much of a cure for PE. So i went to next step... Stopped tadalafil and got tamsulosin 400Mcg daily slow release for 2 weeks. Its a medication that is used for bladder issues like enlarged prostate. Relax pelvic floor. Funny enough that it gave me similar effects as tadalafil, increaed easines of my erections and helped me last a bit longer but not significantly. Same like before around 1 minute. So i went to third step... I have asked my doctor for antidepressants. But not just any. I knew exactly what i wanna try and why... dopamine and serotonin are essential neurotransmitters. Dopamine promotes seminal emission and counterbalance serotonin levels. High serotonin = lower dopamine and vice versa. Serotonin (5ht) binds to the receptors. studies on rats shows that: stimulation of 5-ht1a receptors in rats results in shortening ejaculatory time. Stimulation of 5-ht2c receptors in rats results in delaying ejaculatory time. It is postulated then that PE is due to hypersensitivity of 5ht1a or hyposensitivity of 5ht2c receptors towards serotonin binding. I have used paroxetine 20mg daily (SSRI drug) for 2 days. On second day on paroxetine i had sex. I have lasted 12 minutes!!! without even bothering about relaxing anything. Paroxetine works as agonist (binds) to the 5ht1a and 5ht2c and improves number of serotonin binding to these receptors. i guess my results were due to serotonin stimulating 5ht2c and slight reduction of hypersensitivity of 5ht1a due to massive ammount of serotonin binding to it (desensitization of receptors). I have stopped taking it now cos it caused me insomnia and other side effects. More studies shows that small ammounts of serotonin chronically increase sensitivity of 5ht1a = PE Studies shows that 5ht2c is related to circadian rhytm (day / night body clock) and also to the sex drive and apetite and stress. Studies shows that either using agonist or antagonist on 5ht2c receptors does not entirely mean that it will be desensitized or sensitized. Studies showed that alfa males in monkeys had twice as much serotonin levels as other males. Tendency remained same as nomal monkey became alfa male - increase in serotonin. Summarizing everything. Key to normality and riddance of PE is in serotonin levels. Exposing yourself to sunlight / waking up early, going to bed when dark, excercise, social interaction, feeling happy in general improves serotonin levels. Higher serotonin levels will stimulate receptors 5ht2c and also reduce dopamine and will improve ejaculatory times. If you want to go one step further like me i will tell you what my plan is. The short way of desensitizing 5ht1a and sensitizing 5ht2c is fluoxetine as its agonist of 5ht1a and antagonist of 5ht2c. 2 weeks on that crap and then reduce dose (careful - read about serotonin syndrome / sudden withdrawal). And it is proven in studies to work like i explained. But... if you dont produce enough serotonin cos of your lifetyle + diet + mindset after you sort out receptors... they will come back to original state eventually and PE will return. Now my plan is bit different I wanna do it naturally. It is proven in studies that CBD oil desensitize 5ht1a as its partial agonist of that receptor. So im gonna be using that for 3 months. If it comes to 5ht2c it is stimulated when you eat or have sex. so im going to abstinence of sex activity and reduce meals in ammount and to twice a day and do intermittent fasting diet when i do not eat at all for period of time. stress and also dehydration helps to sensitize 5ht2c so give yourself some of that aswell but dont go overboard. I will keep you updated but I know i will succeed. And you will too. All the best
PE is more psychological than anything else. When you start m very early and you rush through it to reach o , the brain wires itself to give u fast o's. To change this it will take a bit of time rewiring the brain to delay the o.
